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Short-term respiratory effects of e-cigarettes in healthy individuals and smokers with asthma

Andreas S Lappas, Anna S Tzortzi, Efstathia M Konstantinidi, et al.
Respirology 2018;23:291–7

With electronic cigarettes (e-cigarettes) rising in popularity as effective smoking cessation aids, research has focused on the health effects associated with using these devices. In particular, how they affect the lung function of asthmatic patients is of important consideration. In this study, Andreas S Lappas and colleagues aimed to explore the differences between the respiratory effects of e-cigarette vapour in both healthy and asthmatic patients who smoke. The study exposed 27 healthy smokers (HS) and 27 smokers with mild asthma (MA) to controlled conditions, in which the participant use a third-generation e-cigarette without the coil or e-liquid (meaning vapour was not produced), and experimental conditions (in which the device included all components and vapour was produced) for five minutes. The participants’ impulse oscillometry impedance, lung resistance, reactance and fractional exhaled nitric oxide (FeNO) were then measured at 0, 15 and 30 minutes after each condition. Results highlighted that control sessions produced no significant changes in lung function, while experimental sessions induced a significant increase in respiratory system resistance. In addition, the MA group exhibited higher baseline values and a greater respiratory effect after e-cigarette use compared with the HS subjects. This experiment highlighted single sessions of e-cigarette vaping induces mechanical and inflammatory effects on the respiratory system. These were intensified and more prominent in smokers with asthma.

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